Postgraduate Programs • MESTRADO E DOUTORADO EM ONCOLOGIA CLÍNICA, CÉLULAS-TRONCO E TERAPIA CELULAR • MESTRADO PROFISSIONAL EM HEMOTERAPIA E BIOTECNOLOGIA
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Curricular structure

The curriculum of the Professional Master Degree in Biotechnology and Hematology includes mandatory and elective subjects that will allow the student an orientation of their training.
The curriculum of the course includes classic basic subjects addressed in order to develop in students the essential concepts of Hematology, Transfusion Medicine, Cell Therapy, Molecular Diagnostics, Biotechnological Processes and Biotechnology and provide them with training to perform at different levels of the area. The proposed curriculum is focused in the following areas:

1) Hematology
1.1. Transfusion Medicine;
1.2. Cell Therapy.

2) Biotechnology
2.1. Molecular Diagnostics;
2.2. Biotechnological Processes.

Compulsory Courses – Hematology:

• Hematology Unit Management.
Understand the basic principles governing the management of a Hematology Unit including health principles, legal and quality management, including certification and accreditation programs.

• Collection, donor screening, collection and service to donors.
Understand the basic principles that guide blood donation including rules and funding methodologies in the community of candidates for blood donation. It also includes national criteria laid down by the current rules and the current literature for donor screening and blood collection bags, in addition to the care for ineligible donors or for patients who have adverse reactions to donation.

• Research Methodology.
Understand the basic principles that guide the development of research in the health field including guidance on literature and preparation of monographs.

• Processing, storage and distribution of blood, blood components and blood products.
It comprises the basic principles of the production of blood products and modification as well as its storage and distribution. It also includes inventory management techniques of blood products and blood products and maintaining the traceability of the products distributed.

• Detection of transfusion-transmitted infections.
Understand the basic principles related to infectious agents transmitted by transfusion, screening tests used in hemotherapy services and confirmatory testing and quality control applied to a serology lab.

• Immuno-hematology
It comprises the basic principles of the area of basic and advanced immuno-hematology  with an emphasis on immuno-hematological screening of blood donors, the basic routine of pre-transfusion testing, the association of anti-erythrocyte antibodies research in technical immunohematology complementary to erythrocyte phenotyping, antibody titration, among others. It also includes notions about the clinical applications of immuno-hematology and quality control reagents and calibration of centrifuges.

• Molecular methods applied to Hematology
It comprises lectures on the basic principles in Molecular Biology, genomic structure of erythrocyte antigens, genomic structure of the main transmissible infectious agents in blood and the molecular basis of genetic diseases. It also includes practical classes for isolating nucleic acids, molecular tests the interpretation of genotyping of blood group antigens, application and interpretation of molecular biology tools in clinical diagnosis of infectious and genetic diseases, and leukemias.

• Stem cells
It comprises lectures on concepts, properties and applications of stem cells including three kinds of bone marrow or umbilical cord blood stem cells  and human embryonic stem cells. It also includes practical lessons on the isolation procedures, culture, growth, their characterization and differentiation potential.

• Quality Control in Hematology.
Understand the basic principles of Quality Control in Hematology including techniques for performing the tests, interpretation and guidance on the measures to be adopted. It also includes guidance on validation processes, equipment and reagents.

• HLA system.
Understand the basic principles of the methodologies applied in histocompatibility laboratory.

• Cell Cryopreservation.
It comprises the basic principles of the methodologies used in the processing and cryopreservation of cells for clinical use and to count HSC.

• Apheresis.
It comprises the basic principles of cell collection procedures for clinical use by apheresis and therapeutic apheresis procedures.

• Hemoglobin.
Understand the basic principles of genetic disorders that compromise the hemoglobin and its diagnosis.

• Transfusion Medicine.
Understand the basic principles of transfusion medicine activities in the light of existing rules and current literature.

Compulsory Courses – Biotechnology:

• Introduction to Biotechnology and Bioprocess
It comprises learning the principles of Biotechnology and Bioprocess, presenting from historical examples of biotechnological processes and products to the current state of biotechnology and bio-processes provided by advances in scientific studies.

• Bioinformatics Applied Biotechnology
It comprises the study of bioinformatics foundations to address the usual questions that arise in the routine of a molecular biology laboratory.

Other Disciplines – Biotechnology area:

• Research Methodology .
Understand the basic principles that guide the research development in the health field including guidance on literature and preparation of monographs.

• Biochemistry
It comprises a review of the basic principles of general biochemistry, analysis of metabolic pathways of eukaryotic and prokaryotic cells to interpret their energy and nutritional characteristics.

• Cell Biology
It comprises the knowledge about the structure and functioning of the cell, as well as their interactions with the extracellular environment, and relate this knowledge with potential biotechnological applications.

• Molecular Biology
It comprises the knowledge of molecular methods applied in the development of biotechnological processes in different areas of research. In addition to providing the basic concepts in Molecular Biology, as well as tools of recombinant DNA technology.

• Fundamentals of Laboratory Practice
It includes the study of fundamental concepts of laboratory practice, introducing concepts of applied analytical chemistry and instrumental analysis, mainly intended for the daily life of a molecular biology laboratory.

• Advanced Studies in Biotechnology
It comprises the updating of students in topics of interest and application in the field of biotechnology, such as biotechnological processes, development of biopharmaceuticals, new areas of research in biotechnology, molecular diagnostic methods and genetic engineering.

• Immunology Applied to Biotechnology
It comprises the consolidation and/or updating of concepts, providing integration and critical view of knowledge in immunology applied to the field of Biotechnology.

• Biotechnological Processes with animal cells
It comprises the preparation of professionals to work in the field of biotechnological processes using animal cells. To this end, it seeks to integrate concepts of biochemical engineering, unit operations and biology to enable the student to develop processes related to these areas.

• Mammalian cell culture
It comprises theoretical and practical procedures for isolation, expansion and cryopreservation of primary mammalian cells and culture of adherent and non-adherent cell lines. It provides knowledge of the different sources, surface markers and forms of characterization of mammalian cells and the discussion of current legislation for the production of cellular products following good handling practices.

• Genetic engineering for the production of recombinant protein and genetically modified organisms
It comprises the construction of knowledge about the basics of genetic engineering, history, current applications and perspectives, which have allowed the elucidation from basic questions of biology and cellular reprogramming and the development of recombinant products with applications in several areas of health, with a particular focus related to the production of recombinant proteins in human cells, genetically modified organisms and the current perspectives of synthetic biology.

• Separation and Purification Processes
It comprises a basic knowledge of biochemical methods used for isolation, purification and characterization of macromolecules, particularly proteins and peptides.

Other Subjects – Hematology Areas and Biotechnology:

• Molecular Diagnosis
It comprises the study of laboratory concepts and techniques relating to molecular diagnosis aimed at identifying genetic changes associated with hereditary diseases, and detection of infectious disease causing pathogens.

• Diagnosis of hematological malignancies
It comprises knowledge of the laboratory diagnosis of hematopoietic neoplasms for the purpose of clinical research and research methods, including cytological, immunophenotypic and molecular  characterization, and cytogenetics of cancer cells.

• Cell-mediated therapy
It comprises the presentation of the use of cells as biotechnological tools for therapeutic purposes, introducing the basics of the rules governing the production of cells for therapeutic purposes and offering the student an overview of therapeutic strategies based on cells.

• Quality Management
comprises the study of the theoretical and practical bases of management of quality programs in biotechnological processes

• Biosafety and Bioethics
It comprises the study of the basic principles of biosafety in accordance with current regulations and current literature. Present and discuss the professional security conditions working in laboratory settings, the necessary conditions for responsible management of human, animal, environmental responsibility and debate issues related to bioethics involving no moral consensus existence and the moral responsibility of scientists in their research and its applications.

• Entrepreneurship
It includes the development of entrepreneurial and innovative behavior; identifying new business opportunities, analysis of financial viability of the business; developing a business plan for small businesses; investigation of psychological and sociological elements that influence entrepreneurs.
In addition to working in the profile, motivations and the specific skills of the entrepreneur.

• Biostatistics
It comprises the understanding of fundamental concepts of statistics, studying the development of techniques, presentation and data analysis. Encourage the student to understand, interpret and criticize the results of their work and other researchers. To enable students to understand the basic principles of Bayesian statistics and their applications in biotechnology studies

• Intellectual Property and Technology Transfer
It comprises the critical awareness of students to the importance of innovation in the scientific, academic and business context; critical analysis of the process of technological innovation in companies, the implementation of technological function and its relationship with other areas: marketing, HR, finance and production. In addition to presenting the public policies focused on innovation and the development of lines intended for these purposes.

 

SUMMARY OF PROGRAM COURSES 

MANDATORY SUBJECTS

Initials Subject Name Responsible professor Week workload Nº weeks Nº credits Areas of concentration (*)
AT P/S E
HEB

Hematology Unit Management

  • Dimas Tadeu Covas
  • Eugênia Maria Amorim Ubiali
11 13 6 1 2 1
HEB

Donor recruitment, screening, collection and service to donors

  • Dimas Tadeu Covas
  • Karen Lima de Prata
  • Benedito de Pina Almeida Prado Junior
10 20 0 1 2 1
HEB

Research Methodology

  • Dimas Tadeu Covas
  • Marisa Ramos Barbieri
  • Lewis Joel Greene
3 4 8 10

      10

1 e 2
HEB

Processing, storage and distribution of blood, blood products and blood derivatives

  • Dimas Tadeu Covas
  • Karen Lima de Prata
  • Gil Cunha De Santis
7 23 0 1 2 1
HEB

Detection of transfusion-transmitted infections

  • Dimas Tadeu Covas
  • Simone Kashima Haddad
  • Fabíola Attié de Castro
9 15 6 2 4 1
HEB

Immuno-hematology

  • Kelen Cristina Malmegrin Farias
5 20 0 3 5 1
HEB

Molecular methods applied to hemotherapy

  • Simone Kashima Haddad
  • Fabíola Attié de Castro
11 13 6 1 2 1
HEB

Stem cells

  • Aparecida Maria Fontes
10 14 6 1 2 1 e 2
HEB

Quality Control in Hematology

  • Dimas Tadeu Covas
  • Eugênia Maria Amorim Ubiali
5 8 2 3 3 1
HEB

HLA System

  • Eduardo Antonio Donadi
2 22 6 1 2 1
HEB

Cell cryopreservation

  • Eduardo Magalhães Rego
  • Belinda Pinto Simões
  • Gil Cunha De Santis
6 18 6 1 2 1 e 2
HEB

Apheresis

  • Dimas Tadeu Covas
  • Benedito de Pina Almeida Prado Junior
4 11 0 1 1 1
HEB

Hemoglobinopathies

  • Marco Antonio Zago
2 6 7 1 1 1
HEB

Transfusion Medicine

  • Dimas Tadeu Covas
  • Ivan Lucena Ângulo
  • Gil Cunha De Santis
2 4 0 15 6 1
HEB

Biochemistry

  • Vitor Faça
  • Elisa Maria Carbolante
3 5 7 5 5 2
HEB

Cell Biology

  • Lindolfo Meireles
  • Aparecida Maria Fontes
4 0 1 12 4 1 e 2
HEB

Molecular Biology

  • Rodrigo Alexandre Panepucci
  • Simone Kashima Haddad
3 5 7 5 5 1 e 2
HEB

Fundamentals of Laboratory Practice

  • Rodrigo Alexandre Panepucci
  • Simone Kashima Haddad
2 6 4 5 4 1 e 2
HEB

Introduction to Biotechnology and Bioprocess

  • Dimas Tadeu Covas
  • Kamilla Swiech
  • Cláudio Suazo
2 1 2 12 4 2
HEB

Advanced Studies in Biotechnology

  • Wilson Araújo da Silva Junior
  • Kamilla Swiech
  • Roberto Passetto Falcão
0 2 3 15 5 2

 

(*) 1 – Hematology / 2 – Biotechnology

7.2 – OTHER SUBJECTS 

Initials Subject Name Responsible professor Week workload Nº weeks Nº credits Areas of concentration  (*)
AT P/S E
HEB

Bioinformatics
Applied to Biotechnology

  • Wilson Araújo da Silva Junior
3 15 9 5 9 2
HEB

Immunology Applied to
Biotechnology

  • Kelen Cristina Malmegrin Farias
  • Eduardo Antonio Donadi
3 5 7 4 4 2
HEB

Biotechnological Animal Cell Processes

  • Dimas Tadeu Covas
  • Kamilla Swiech
  • Cláudio Suazo
2 1 2 15 5 2
HEB

Molecular diagnostics

  • Rodrigo Alexandre Panepucci
  • Simone Kashima Haddad
3 5 7 5 5 1 e 2
HEB

Cell Culture in Mammals

  • Dimas Tadeu Covas
  • Lindolfo Meireles
  • Maristela Delgado Orellana
2 2 3 15 7 2
HEB

Genetic Engineering for Recombinant Protein Production and Genetically Modified Organisms

  • Aparecida Maria Fontes
  • Flávio Meirelles
  • Felipe Perecin
5 7 12 5 8 2
HEB

Separation and Purification Processes

  • Lewis Joel Greene
  • José César Rosa
  • Clarice Izumi
4 5 6 5 5 2
HEB

Diagnosis of Hematologic Neoplasms

  • Eduardo Magalhães Rego
  • Belinda Pinto Simões
  • Rodrigo Tocantins Calado
5 5 5 4 4 1 e 2
HEB

Cell-mediated therapy

  • Dimas Tadeu Covas
  • Lindolfo Meireles
  • Marco Antonio Zago
4 0 5 5 3 1 e 2
HEB

Quality management

  • Dimas Tadeu Covas
  • Eugênia Maria Amorim Ubiali
3 5 7 4 4 1 e 2
HEB

Biosafety

Bioethics

  • Dimas Tadeu Covas
4 3 5 5 4 1 e 2
HEB

Entrepreneurship

  • Dimas Tadeu Covas
  • Eduardo Cicconi
3 5 7 4 4 1 e 2
HEB

Biostatistics

  • Edson Martinez
4 7 12 5 3 1 e 2
HEB

Intellectual Property and Technology Transfer

  • Simone Galina
  • Geciane Porto
  • Julio César Marchini
4 7 10 5 7 1 e 2